Interplay between autophagy and metabolism in Ras mutation-induced tumorigenesis
نویسندگان
چکیده
منابع مشابه
Interplay between autophagy and metabolism in Ras mutation-induced tumorigenesis.
M acroautophagy (hereafter referred to as autophagy) or ‘self-eating’ is a lysosomal degradation pathway and plays a role in the breakdown of disordered intracellular organelles, such as peroxisomes (pexophagy), mitochondria (mitophagy), endoplasmic reticula (reticulophagy) and ribosomes (ribophagy), as well as providing for controlled recycling of macromolecules during cellular adaption and pa...
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Autophagy is a catabolic pathway used by cells to support metabolism in response to starvation and to clear damaged proteins and organelles in response to stress. We report here that expression of a H-ras(V12) or K-ras(V12) oncogene up-regulates basal autophagy, which is required for tumor cell survival in starvation and in tumorigenesis. In Ras-expressing cells, defective autophagosome formati...
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Numerous studies have established a link between autophagy and aging; however, the relationship has not been clearly defined. Aging is a very complex process caused by the accumulation of various factors due to the gradual failure of cellular maintenance. Recent studies have shown that autophagy reduces the stress responses induced by starvation, reactive oxygen species, and the accumulation of...
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ژورنال
عنوان ژورنال: Asian Journal of Andrology
سال: 2011
ISSN: 1008-682X,1745-7262
DOI: 10.1038/aja.2011.31